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The model had an area under the receiver operating characteristic curve of 0.71 (95% CI, 0.63–0.78).Ĭonclusions: Among patients without intrinsic LBBB undergoing CRT, upgrade from pacemaker and AVN ablation were favorable factors in achieving CRT response and better long-term outcomes.
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Eight clinical variables were automatically selected to build a nomogram model and predict CRT response. Patients undergoing AVN ablation had a lower mortality rate than those without ablation. Patients with right bundle-branch block had a low response rate (39.2%). Patients with CRT upgrade from pacemaker or atrioventricular node (AVN) ablation had a greater odds of CRT response than those patients who had new implant, or who did not undergo AVN ablation.
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Six months after CRT, 47.8% of patients demonstrated improvement of left ventricular ejection fraction by more than 5%. Results: 761 patients without intrinsic LBBB were identified. Results were used to develop the nomogram model. Logistic regression and Cox proportional hazards regression analysis were performed for the odds of response to CRT and risk of death, respectively. Methods: We searched electronic health records for patients without intrinsic LBBB who underwent CRT at Mayo Clinic. Objective: We sought to develop a nomogram model to predict response to CRT in patients without intrinsic LBBB. Background: Response rates for cardiac resynchronization therapy (CRT) in patients without intrinsic left bundle-branch block (LBBB) morphology are poor.